The Clotting times

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چکیده

After two years of producing The Clotting Times we at the ECAT have now chosen a brand new, fresh layout. In the content you can see that every rubric from now on has its own colour. In this way you can easy recognize a particular item in the pages which follow. Every issue will start with a “focus article” which in this issue gives you an update on pre-analytical issues in platelet function testing. This article seeks to heighten awareness that lack of attention to preanalytical conditions can significantly impact results from platelet function testing. The next section is “ECAT information”. Based on results from the ECAT surveys, the effect of Rivaroxaban on haemostasis assays is described in this issue. In the section entitled “Literature Review” we would like to present highlights from recent publications. The current issue gives a synopsis of the publication, Lupus anticoagulant testing: analyzing fresh samples after a single centrifugation and after a 6-8 hr delay (P. Froom and M. Barak. Clin Chem Lab Med 2012; 50: 367 – 370). The editorial board hopes that you will appreciate our new design and enjoy reading this and future issues.

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منابع مشابه

Clotting time analysis of citrated blood samples is strongly affected by the tube used for blood sampling.

Our aim was to establish whether differences in clotting times for recalcified blood and plasma samples might be explained by the use of different blood collection tubes. Samples obtained from different plastic vacuum tubes were recalcified and clotting times determined by free oscillation rheometry. The clotting times for blood collected in Vacutainer (Becton Dickinson, Rutherford, New Jersey,...

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Thrombin clotting activity measurement and standardization with lyophilized plasma.

Thrombin-induced clotting times were inversely proportional to fibrinogen concentrations within the range of 98 to 2900 nmol/L; these reciprocal velocity measurements had units of seconds per clot. By analogy with classical enzyme kinetics, we defined rectangular hyperbolic parameters where Km(clot) ranged from 0.14 to 0.56 mumol/L and kclot from 0.020 to 0.075 clot per second. Specificity rati...

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Microsciadin, a New Milk-Clotting Cysteine Protease from an Endemic Species, Euphorbia microsciadia

In the present work, a new branch of biotechnological advantage of the latex of an endemic perennial plant, Euphorbia microsciadia has been introduced. A novel cysteine protease, designated as microsciadin, was purified from the latex of Euphorbia microsciadia by a combination of sequential usage of SP-Sepharose Fast Flow column in two different pHs and a final gel filtration ...

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Purification and Characterization of Milk Clotting Enzyme Produced by Rhizomucor Rmiehei

Milk clotting enzyme (M CE) produced by: Rhizomucor miehei was purified and characterized.The enzyme was purified 220.29-fold with specific activity about 14444.2 U/mg protein byultrafiltration, ammonium sulfate fractionation, Sephacryl S-300 chromatography. The maximumenzyme activity was at 65°C.The milk clotting activity was decreased steadily as pH is increased and indicated maximumactivity ...

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Association between Intra-Circuit Activated Clotting Time and Incidence of Bleeding Complications during Continuous Renal Replacement Therapy using Nafamostat Mesilate: a Retrospective Pilot Observational Study.

It has been proposed that anticoagulant activity during continuous renal replacement therapy with nafamostat mesilate can be monitored by using intra-circuit activated clotting time. However, it is still unclear whether activated clotting time would be useful for this purpose. We conducted a retrospective study and included 76 patients who required continuous renal replacement therapy using naf...

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Multicentre evaluation of the Thrombotest International Sensitivity Index used with a steel ball coagulometer.

AIM To compare the International Sensitivity Index (ISI) of the Thrombotest reagent used with a steel ball coagulometer (KC) to the ISI of the same reagent used with the manual (tilt tube) technique. METHODS The study was carried out by eight laboratories using their own KC instrument and method of testing. All laboratories used the same batch of Thrombotest to determine the clotting times of...

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تاریخ انتشار 2012